Israeli Scientists Make Breakthrough in Understanding Genetic Causes of ADHD

Israeli researchers from Ben-Gurion University of the Negev and Soroka-University Medical Center have made a breakthrough in understanding the genetic causes of attention deficit hyperactivity disorder (ADHD).

The study, which was published in Nature Communications, focused on the gene CDH2, which encodes N-cadherin and is responsible for brain synapse activity and formation. The study found that a mutation in CDH2 alters this activity, which affects molecular pathways and dopamine levels in the ventral midbrain and prefrontal cortex, both of which are involved in ADHD. The researchers used CRISPR to insert this type of mutation in homologous mouse genes, causing hereditary hyperactivity.

This finding could lead to a better understanding of ADHD and potential new treatments. The researchers plan to continue their studies at BGU’s National Institute for Biotechnology in the Negev (NIBN).

ADHD is a neurological disorder that is characterized by inattention, hyperactivity, impulsivity, and difficulty focusing. It is one of the most common disorders that first appear during childhood. While it is evident that there is a genetic predisposition to ADHD, the exact genes that cause it are unknown.

Adults with ADHD may have difficulty paying attention, impulsiveness, restlessness, poor time management, difficulty multitasking, excessive activity or restlessness, poor planning, low frustration tolerance, frequent mood swings, trouble completing tasks, and trouble coping with stress. The diagnosis of ADHD in adults can be difficult because certain ADHD symptoms are similar to those caused by other conditions, such as anxiety or mood disorders. ADHD is diagnosed only when symptoms are severe enough to cause ongoing problems in more than one area of your life.