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Cancer Discovery in Novel Seaweed Extracts

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Image Source: Tasmanian Times

Breakthrough research confirms two unique compounds extracted from seaweed have significant cancer inhibiting properties.

A series of animal studies undertaken at the prestigious McGovern Medical School, University of Texas Health Science Center in Houston (UTHealth) have shown that the two seaweed extracts – known as fucoidans – reduced tumor growth in select cancers and significantly improved the effectiveness of the common chemotherapy drug tamoxifen.

The breakthrough demonstrates the potential for fucoidan to be safely used as a complementary cancer therapy alongside traditional chemotherapy.

The extracts, developed and manufactured by Australian biotechnology company Marinova Pty Ltd, were tested in six human tumour mouse models, including cervical, breast and ovarian cancers. Fucoidan extracts were orally administered to mice for 30 days and compared to controls.

Ingestion of the fucoidan extracts decreased the growth of a human ovarian cancer tumour line by up to 33% and a human cervical cancer tumour line by up to 70%.

The same breast and ovarian cancer models were also used to assess fucoidan activity in combination with paclitaxel or tamoxifen, two commonly used chemotherapy agents. The results showed fucoidan considerably improved the efficacy of tamoxifen towards breast cancer. Fucoidan decreased breast cancer tumour growth in this animal model by up to an additional 26% when taken alongside tamoxifen.

These findings build on results from a series of in vitro studies performed under the same research program. The in vitro studies showed that the two fucoidan extracts did not interfere with key metabolic pathways necessary for chemotherapy function and directly inhibited a number of human cancer cell lines. Strong synergistic activity between fucoidan and both paclitaxel and tamoxifen was also observed, as well as additive activity with topotecan.

Associate Professor Dr. Judith A. Smith, Director of the Women’s Health Integrative Medicine Research Program at UTHealth, led the research project and commented on the findings:

“This was the first research program to comprehensively assess the metabolism of fucoidan compounds for possible chemotherapy drug interactions.”

“A pharmacokinetic study is now underway at UTHealth to further assess safety and observe quality of life parameters in human cancer patients.”

Adding to these findings, a further study in the research program found that both fucoidan extracts enhanced the immune function of cancer-affected mice. Immune markers immunoglobulin G (IgG) and interleukin 6 (IL-6) were both significantly modulated in fucoidan-fed mice, with a 500% increase in IgG levels relative to controls after 1 week.

IgG is the main type of antibody found in humans. It helps control infections by binding to pathogens (such as bacteria and viruses) and alerting circulating immune cells. IgG levels are often suppressed in oncology patients, making them vulnerable to a wide range of infections.

Dr Helen Fitton, Chief Scientist at Marinova, highlighted the importance of these findings:

“These results confirm the potential for fucoidan to help restore functional immunity in cancer patients. To have identified a safe, natural compound that has such a significant effect on immunity in an oncology setting is really quite remarkable.”

The two clinical studies have been published in the journal, Integrative Cancer Therapies:

“Evaluation Fucoidan Extracts From Undaria pinnatifida and Fucus vesiculosus in Combination With Anticancer Drugs in Human Cancer Orthotopic Mouse Models” 

“Pre-clinical evaluation of safety of fucoidan from Undaria pinnatifida and Fucus vesiculosus for use by oncology patients”

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Meet the Couple That Guides Together

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Image source: www.blog.google

Local Guides come from all over the world, and they form a community of people who share their knowledge on Google Maps—everything from photos and reviews of local restaurants to accessibility information.

And for one long-distance couple, the Local Guides community helped bridge the miles between Malaysia and Bangladesh. Sumaiya Zafrin Chowdhury and Pavel Sawar got married in 2013 and became Local Guides in 2015. Nine months ago, Pavel moved to Malaysia to study information technology, and Sumaiya stayed in Bangladesh to pursue her career as an entrepreneur, community leader and social worker.

In honor of Valentine’s Day, we’re spotlighting this Local Guides love story. We spoke to Sumaiya and Pavel about how they enjoy the community together, and how Local Guides helps them stay connected while they’re apart.

Tell us where it all began: how did you meet?

Pavel: I first saw Sumaiya at a social work event in 2012…first look, fell in love. One day I went to visit a slum, and saw her there serving underprivileged people. I am fascinated by her work.

You’ve been apart for nine months. How do you make a long-distance relationship work?

Sumaiya: I went to Malaysia twice and we had great fun together. We discovered many places. We try to meet every three months. We manage our relationship through social media, especially via video call and chatting through Google Hangouts. We share songs and pictures also.

When you’re in the same place, what are your favorite things to do together?

Pavel: Sumaiya and I love to travel very much. As Local Guides, we also love to arrange meet-ups together and do social work and community activities.

So you connect over Local Guides together?

Sumaiya: Yes, we use Local Guides community and Maps to plan activities and date nights. Sometimes, we celebrate our special days through mapping. We plan to visit new places and compare our points. Mapping and meet-ups are our favorite part.

Pavel: Every day we discuss Local Guides. When Sumaiya arranges a meet-up, I try to help her. When I arrange one Sumaiya helps me lot. We discuss our contributions, photo views, quality reviews, etc. Local Guides helps us to spend more time together. Local Guides makes our relationship closer.

Why did you both decide to join Local Guides?

Pavel: Personally I love traveling, taking photos, and eating at different restaurants. As a traveler and explorer, I use Google Maps almost every day. I love to discover new places and I love to take photos. With Local Guides, I can help any other travelers also. I feel I am helping people in my community. Local Guides are like my family. It’s now part of my life.

Sumaiya: Pavel introduced me to Local Guides back in 2015. I joined in March 2015 because I love technology, traveling and photography. With Local Guides, I can do something positive for my society; that’s why I was interested to join.

We recently did a post about seven kinds of Local Guides. Which ones do you identify with?

Pavel: The Visualist and the Trailblazer.

Sumaiya: I identify as a Fact Hunter because I want all to know real information about a place…and Trailblazer because I love to discover and add new places.

For those that are new to Local Guides, what advice do you have for someone just getting started?

Pavel: First, spend some quality time on Local Guides Connect. See how others in the community are doing. Arrange meet-ups. Please contribute on Local Guides to be a good citizen. Don’t focus on points.

Sumaiya: Upload proper pictures in proper places. Post useful and informative reviews that one can easily understand. Do meet-ups so that people can know about this community. And for the people of my own country, I want to advise them: please contribute more, add new places, and do your best reviews so that tourists can understand that our country is very beautiful.

What do you appreciate most about each other?

Sumaiya: Pavel is very punctual. This is the part of his character I like the most. He’s also a very trustworthy and hard-working person. He is very caring…he always supports me and appreciates my work.

Pavel: I can’t appreciate Sumaiya in a single sentence. Sumaiya is not only a good wife, she is also a good mentor for me. She gives support to me for my every good work. Without her I am nothing.

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Play Arena of Valor and Win an OPPO F5 this Long-Weekend

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Image source: OPPO PR

OPPO Philippines teamed up with Arena of Valor, the fastest growing 5v5 multiplayer online battle arena in the Philippines, for something exciting this long weekend. From February 16-18, 2018, Arena of Valor will be having a special Lunar Year offer by giving red packets for every 5v5 Grand Battle or Ranked game which contains in-game items and the rare OPPO F5 Red!

Each day, players may acquire up to 2 red packets which could contain 8 Hero Shards, 8 Skin Shards or the grand prize – the OPPO F5 Red! Players are encouraged to play over the long weekend for a chance to win one out of the five OPPO F5 Red smartphones to be given away! Experience seamless gaming with OPPO smartphones featuring its game acceleration, stop unwanted notification feature, and effortless boost system, best for playing games like Arena of Valor. Get to enjoy games in the best way you can with the latest 2.5GHz Octa-Core processor on the OPPO F5 series and A83, and its 18:9 Full Screen Display.

For more information, customers may visit https://www.oppo.com/ph/. They can also follow OPPO on Facebook via https://www.facebook.com/OPPOPH/ for the store list and latest updates. Arena of Valor is available on Google Play store for download.

OPPO PR

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Two #Teampixel Photographers Say “I Do” to Pixel 2

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enny and Colin Hayles are professional photographers (Jenny does weddings and Colin captures nature and wildlife) and proud #teampixel members. Knowing that a Pixel 2 can take high-quality photos, they wanted to see how their phones would fare in the most picture-worthy setting: a wedding. We spoke with Jenny and Colin about their experience using a Pixel 2 at an experimental wedding photo shoot.

 

Tell us about your wedding experiment. How’d you come up with the idea?
Colin: The concept developed when one of my shots was featured on #teampixel, and I realized just how amazing the Pixel camera was. At first, I wanted to show that wedding guests have no excuse for taking lousy pictures if you have a Pixel. But Jenny and her creative team (shout out to our planner from Jaqueline Rae Weddings) went to the next level—she wanted to shoot professional wedding photos with a Pixel. Before we tried it out at a real wedding, we had to see what the Pixel was capable of—from details, to portraits, to action shots. We simulated the details of a wedding day—the gown and tux, rings, stationery, cake and flowers—and recruited our friends Michele and Tom (a real-life couple) to be our models. We used only a Pixel 2 (no reflectors, lights, or tripods) for the entire photo shoot. The results were, I think, better than any of us dared to hope.

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Lenovo Continues Support for Youth Organizations, Named Exclusive Technology Partner Anew of TAYO Awards Foundation

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Image source: LENOVO PR

Lenovo, one of the world’s biggest technology companies, is once again the official technology partner of the Ten Accomplished Youth Organizations (TAYO) Awards Foundation, Inc., the country’s premier award-giving body that recognizes and supports the outstanding contributions of youth organizations in the country.

“Being one of the most innovative global tech companies, Lenovo’s thrust in championing exceptional projects by the youth stands parallel with what the TAYO Awards Foundation believes in. Their unwavering support helps us empower youth groups and organizations in the Philippines to innovate and actively contribute to our society. Together, TAYO Awards Foundation and Lenovo Philippines acknowledge and aid their outstanding efforts,” said Patricia Matute, Executive Director of TAYO Awards Foundation, Inc..

Now on its 15th year, the TAYO Awards is an annual search for exceptional organizations of young Filipinos that have made notable contributions to the progress and betterment of their communities or schools through innovative and valuable projects.

“Our ‘Different is Better’ philosophy is built around a fundamental belief that innovation is the best way to address challenges and embrace progress. We are pleased to once again partner with TAYO Awards Foundation. This partnership gives us the perfect opportunity to recognize our hardworking youth who are relentless in making the world a better place through technology,” said Michael Ngan, Country General Manager of Lenovo Philippines.

As technology partner, Lenovo will be providing the laptops and tablets that will be used throughout the screening and awarding process for the TAYO 15 Awards. Lenovo will also be awarding all 10 winners Lenovo devices.

Further, Lenovo will be awarding a special citation to one carefully selected organization. Called ‘Lenovo Outstanding Tech Visionary, the award is given to the organization that “embodies the ‘Different is Better’ mindset by being unafraid to stand out and be different, and leverages technology to affect positive change in society.”

Last year, Davao-based social enterprise GO2 Virtualahan was conferred said award.

Lenovo has been the exclusive technology partner of the TAYO Awards Foundation, Inc. for the TAYO Awards since 2012.

LENOVO PR

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